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Miao, Z.-F., Lewis, M. A., & Cho, C. J. (2020). A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle. Developmental Cell, 55(2), 178–194.e7. 
Added by: Dr. Enrique Feoli (24/05/2023, 17:54)   Last edited by: Dr. Enrique Feoli (05/05/2024, 18:54)
Resource type: Journal Article
DOI: 10.1016/j.devcel.2020.07.005
ID no. (ISBN etc.): 1534-5807
BibTeX citation key: Miao2020
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 Categories: BioAcyl Corp, BioAcyl Corp
Subcategories: Cell plasticity, Post-injury Regeneration
Creators: Cho, Lewis, Miao
Collection: Developmental Cell		 Views: 2/242
Abstract

• Dedicated genes govern paligenosis, a conserved cellular regeneration program

• DDIT4 first blocks mTORC1, inducing massive autophagy to downscale the cell

• p53 activation continues mTORC1 suppression to maintain cell quiescence

• IFRD1 suppresses p53 to reinduce mTORC1 and license progression into the cell cycle

https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30579-7


Added by: Dr. Enrique Feoli  Last edited by: Dr. Enrique Feoli
Notes
Publisher: Elsevier
  
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