| Ordovas-Montanes, J., Beyaz, S., Rakoff-Nahoum, S., & others. (2020). Distribution and storage of inflammatory memory in barrier tissues. Nat. Rev. Immunol. 20(5), 308. |
 
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The flow of information through a naive tissue (part a) or a hypothetical experienced tissue (part b), in which memory has been established, with key regulators at each step highlighted on the side of the vertical flow. Arrows indicate the predominant direction of information flow. By establishing memory in specific cell subsets, such as antibody-producing plasma cells, resident memory CD8+ T cells and epithelial progenitors, the typical flow of information can be ‘inverted’ in a tissue that has inflammatory memory. BRM cell, tissue-resident memory B cell; TH cell, T helper cell; TPM cell, peripheral memory T cell; Treg cell, regulatory T cell; TRM cell, tissue-resident memory T cell. |
