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Fonseca, D., Hand, Timothy W., & Han, S.-J. (2015). Microbiota-dependent sequelae of acute infection compromise tissue-specific immunity. Cell, 163(2), 354–366. Added by: Dr. Enrique Feoli (04/05/2023, 17:13) Last edited by: Dr. Enrique Feoli (04/05/2023, 17:45) |
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| Resource type: Journal Article DOI: https://doi.org/10.1016/j.cell.2015.08.030 ID no. (ISBN etc.): 0092-8674 BibTeX citation key: Fonseca2015 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Inflammation Post resolution Creators: Fonseca, Han, Hand Collection: Cell |
Views: 2/177
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| Abstract |
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Summary Infections have been proposed as initiating factors for inflammatory disorders; however, identifying associations between defined infectious agents and the initiation of chronic disease has remained elusive. Here, we report that a single acute infection can have dramatic and long-term consequences for tissue-specific immunity. Following clearance of Yersinia pseudotuberculosis, sustained inflammation and associated lymphatic leakage in the mesenteric adipose tissue deviates migratory dendritic cells to the adipose compartment, thereby preventing their accumulation in the mesenteric lymph node. As a consequence, canonical mucosal immune functions, including tolerance and protective immunity, are persistently compromised. Post-resolution of infection, signals derived from the microbiota maintain inflammatory mesentery remodeling and consequently, transient ablation of the microbiota restores mucosal immunity. Our results indicate that persistent disruption of communication between tissues and the immune system following clearance of an acute infection represents an inflection point beyond which tissue homeostasis and immunity is compromised for the long-term. Video Abstract
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Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
