BioAcyl Corp
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Niethammer, P. (2016). The Early Wound Signals. Current opinion in genetics & development, 40, 17–22. Added by: Dr. Enrique Feoli (30/04/2023, 17:19) Last edited by: Dr. Enrique Feoli (30/04/2023, 17:22) |
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| Resource type: Journal Article DOI: 10.1016/j.gde.2016.05.001 ID no. (ISBN etc.): 0959-437X BibTeX citation key: Niethammer2016 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Post-injury Regeneration Creators: Niethammer Collection: Current opinion in genetics & development |
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| Abstract |
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Wounding of tissue barriers, such as epithelia, disrupts homeostasis and allows infection. Within minutes, animals detect injury and respond to it by recruitment of phagocytes and barrier breach closure. The signals that activate these first responses are scarcely known. Commonly considered are cytoplasmic factors released into the extracellular space by lysing cells (Damage Associated Molecular Patterns, DAMPs). DAMPs activate transcription through pattern recognition receptors. But the promptness of wound responses is difficult to explain by transcriptional mechanisms alone. This review highlights the emerging role of nonlytic stress signals in the rapid detection of wounds.
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