BioAcyl Corp
BioAcyl Corp |
|
 |
 |
 |
|
Galluzzi, L., Yamazaki, T., & Kroemer, G. (2018). Linking cellular stress responses to systemic homeostasis. Nature Reviews Molecular Cell Biology, 19(11), 731–745. Added by: Dr. Enrique Feoli (29/04/2023, 17:27) Last edited by: Dr. Enrique Feoli (29/04/2023, 17:27) |
 |
| Resource type: Journal Article Published DOI: 10.1038/s41580-018-0068-0 ID no. (ISBN etc.): 1471-0080 BibTeX citation key: Galluzzi2018 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Stress response Creators: Galluzzi, Kroemer, Yamazaki Collection: Nature Reviews Molecular Cell Biology |
Views: 2/188
|
| Abstract |
|
Mammalian cells respond to stress by activating mechanisms that support cellular functions and hence maintain microenvironmental and organismal homeostasis. Intracellular responses to stress, their regulation and their pathophysiological implications have been extensively studied. However, little is known about the signals that emanate from stressed cells to enable a coordinated adaptive response across tissues, organs and the whole organism. Considerable evidence has now accumulated indicating that the intracellular mechanisms that are activated in response to different stresses — which include the DNA damage response, the unfolded protein response, mitochondrial stress signalling and autophagy — as well as the mechanisms ensuring the proliferative inactivation or elimination of terminally damaged cells — such as cell senescence and regulated cell death — are all coupled with the generation of signals that elicit microenvironmental and/or systemic responses. These signals, which involve changes in the surface of stressed cells and/or the secretion of soluble factors or microvesicles, generally support systemic homeostasis but can also contribute to maladaptation and disease.
|
| Notes |
|
Number: 11 Publisher: Nature Publishing Group
|