Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

Bissell, Mina J.; Hines, William C.

doi:10.1038/nm.2328

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Bissell, M. J., & Hines, W. C. (2011). Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nature Medicine, 17(3), 320–329.
Added by: Dr. Enrique Feoli (16/06/2020, 21:21) Last edited by: Dr. Enrique Feoli (16/06/2020, 21:34)

Resource type: Journal Article
DOI: 10.1038/nm.2328
ID no. (ISBN etc.): 1078-8956
BibTeX citation key: Bissell2011
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Categories: Mendeley
Subcategories: Dynamic reciprocity
Creators: Bissell, Hines
Collection: Nature Medicine

Views: 2/287

Abstract

Tumors are like new organs and are made of multiple cell types and components. The tumor competes with the normal microenvironment to overcome antitumorigenic pressures. Before that battle is won, the tumor may exist within the organ unnoticed by the host, referred to as 'occult cancer'. We review how normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state. We also include a discussion of how this information is being tailored for clinical use. {textcopyright} 2011 Nature America, Inc. All rights reserved.