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Isobe, Y., Kato, T., & Arita, M. (2012). Emerging Roles of Eosinophils and Eosinophil-Derived Lipid Mediators in the Resolution of Inflammation. Frontiers in immunology, 3, 270. 
Added by: Dr. Enrique Feoli (25/03/2022, 15:22)   Last edited by: Dr. Enrique Feoli (25/03/2022, 15:26)
Resource type: Journal Article
DOI: 10.3389/fimmu.2012.00270
ID no. (ISBN etc.): 1664-3224
BibTeX citation key: Isobe2012
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 Categories: BioAcyl Corp
Subcategories: Inflammation resolution
Creators: Arita, Isobe, Kato
Collection: Frontiers in immunology		 Views: 3/385
Abstract
Acute inflammation and its resolution are essential processes for tissue protection and homeostasis. Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programs that enable inflamed tissues to return to homeostasis. The mechanisms by which acute inflammation is resolved are of interest, and research in recent years has uncovered new endogenous anti-inflammatory and pro-resolving lipid mediators (i.e., lipoxins, resolvins, protectin, and maresin) generated from polyunsaturated fatty acids (PUFAs). This review presents new insights into the cellular and molecular mechanisms of inflammatory resolution, especially the roles of eosinophils, and a series of omega-3 PUFA-derived anti-inflammatory lipid mediators that they generate.
  
Notes

Proposed mechanisms of eosinophils’ pro-resolving function. Eosinophils play a role in host defense by releasing cytotoxic granule proteins, cytokines/chemokines, and mediators. In addition, eosinophils maintain metabolic homeostasis by promoting alternative macrophage activation in an IL-4- and IL-13- dependent manner. Thus, it is proposed that eosinophils promote resolution of inflammation by blocking PMN infiltration and/or modulating macrophage phenotype through cytokines (e.g., IL-4, IL-13) and/or lipid mediators (e.g., PD1, RvE3).


Added by: Dr. Enrique Feoli  Last edited by: Dr. Enrique Feoli
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