BioAcyl Corp
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Hennings, V., Thörn, K., Albinsson, S., Lingblom, C., Andersson, K., & Andersson, C., et al. The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19. European Journal of Immunology, n/a(n/a). Added by: Dr. Enrique Feoli (25/03/2022, 11:14) Last edited by: Dr. Enrique Feoli (25/03/2022, 11:39) |
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| Resource type: Journal Article DOI: 10.1002/eji.202149655 ID no. (ISBN etc.): 1521-4141 BibTeX citation key: Hennings View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp Subcategories: COVID-19, Human serum IgA Creators: Albinsson, Andersson, Andersson, Eriksson, Hennings, Idorn, Järbur, Lingblom, Paludan, Pullerits, Thörn, Wennerås Collection: European Journal of Immunology |
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| Abstract |
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The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T-cell proliferation and cytokine secretion, demographic and clinical data, PCR-verified infection, and self-reported symptoms were monitored. The multivariate method OPLS-DA was used to identify immune response patterns coupled to protection from Covid-19. Contracting Covid-19 was associated with SARS-CoV-2-specific neutralizing serum IgG, T cell, IFN-γ, and granzyme B responses to SARS-CoV-2, self-reported typical Covid-19 symptoms, male sex, higher BMI, and hypertension. Not contracting Covid-19 was associated with female sex, IgA-dominated, or no antibody responses to SARS-CoV-2, airborne allergy, and smoking. The IgG-responders had SARS-CoV-2-specific T-cell responses including a cytotoxic CD4+ T-cell population expressing CD25, CD38, CD69, CD194, CD279, CTLA-4, and granzyme B. IgA-responders with no IgG response to SARS-CoV-2 constituted 10% of the study population. The IgA responses were partially neutralizing and only seen in individuals who did not succumb to Covid-19. To conclude, serum IgG-dominated responses correlated with T-cell responses to SARS-CoV-2 and PCR-confirmed Covid-19, whereas IgA-dominated responses correlated with not contracting the infection.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
| Notes |
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_eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.202149655
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