BioAcyl Corp
BioAcyl Corp |
|
 |
 |
 |
|
Serhan, C. N., Gupta, S. K., Perretti, M., Godson, C., Brennan, E., & Li, Y., et al. (2020). The Atlas of Inflammation Resolution (AIR). Molecular Aspects of Medicine, 74, 100894. Added by: Dr. Enrique Feoli (18/03/2022, 20:05) Last edited by: Dr. Enrique Feoli (18/03/2022, 20:09) |
 |
| Resource type: Journal Article DOI: 10.1016/j.mam.2020.100894 ID no. (ISBN etc.): 0098-2997 BibTeX citation key: Serhan2020 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Inflammation resolution Creators: Azzi, Brauer, Brennan, Cesnulevicius, Chiurchiù, Dubourdeau, Filep, Gjorgevikj, Godson, Gupta, Gupta, Haeggström, Hoch, Khan, Kruse, Lescheid, Levy, Li, Perretti, Repsilber, Sala, Särndahl, Schopohl, Schultz, Serhan, Shimizu, Soehnlein, Tripathi, Werz, Wolkenhauer Collection: Molecular Aspects of Medicine |
Views: 3/292
|
| Abstract |
|
Acute inflammation is a protective reaction by the immune system in response to invading pathogens or tissue damage. Ideally, the response should be localized, self-limited, and returning to homeostasis. If not resolved, acute inflammation can result in organ pathologies leading to chronic inflammatory phenotypes. Acute inflammation and inflammation resolution are complex coordinated processes, involving a number of cell types, interacting in space and time. The biomolecular complexity and the fact that several biomedical fields are involved, make a multi- and interdisciplinary approach necessary. The Atlas of Inflammation Resolution (AIR) is a web-based resource capturing an essential part of the state-of-the-art in acute inflammation and inflammation resolution research. The AIR provides an interface for users to search thousands of interactions, arranged in inter-connected multi-layers of process diagrams, covering a wide range of clinically relevant phenotypes. By mapping experimental data onto the AIR, it can be used to elucidate drug action as well as molecular mechanisms underlying different disease phenotypes. For the visualization and exploration of information, the AIR uses the Minerva platform, which is a well-established tool for the presentation of disease maps. The molecular details of the AIR are encoded using international standards. The AIR was created as a freely accessible resource, supporting research and education in the fields of acute inflammation and inflammation resolution. The AIR connects research communities, facilitates clinical decision making, and supports research scientists in the formulation and validation of hypotheses. The AIR is accessible through https://air.bio.informatik.uni-rostock.de
|
| Notes |
|
Hierarchical organization of AIR. (A) The top phenotype layer contains immune cell types, cellular processes/phenotypes and tissue level organization. Clinicians are generally interested in connecting their patient data to this layer. (B) Each process in the top layer is connected to a respective signal flow diagram. The process layer describes key molecules/pathways regulating processes in the top layer. This layer is suitable for research scientists to generate new hypotheses on the mechanistic insights of disease phenotype regulation. (C) The lower layer contains a comprehensive Molecular Interaction Map (MIM) where all the processes are merged together at the molecular level. The layer is also enriched with currently available experimentally validated regulatory information. Each layer provides an opportunity to map and analyze specific data (e.g. Top layer: FACS analysis; middle layer: immune signaling; bottom layer: multi-omics data). Due to the communication across multiple layers, the AIR provides a platform to initiate integrative data analysis. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
