BioAcyl Corp
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Ahmed, S. M. U., Luo, L., Namani, A., & others. (2017). Nrf2 signaling pathway: Pivotal roles in inflammation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1863(2), 585–597. Added by: Dr. Enrique Feoli (22/05/2021, 08:32) Last edited by: Dr. Enrique Feoli (22/05/2021, 08:36) |
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| Resource type: Journal Article DOI: 10.1016/j.bbadis.2016.11.005 ID no. (ISBN etc.): 0925-4439 BibTeX citation key: Ahmed2017 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Nrf2 signaling Creators: Ahmed, Luo, Namani, others Collection: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease |
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| Abstract |
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{Inflammation is the most common feature of many chronic diseases and complications, while playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 contributes to the anti-inflammatory process by orchestrating the recruitment of inflammatory cells and regulating gene expression through the antioxidant response element (ARE). The Keap1 (Kelch-like ECH-associated protein)/Nrf2 (NF-E2 p45-related factor 2)/ARE signaling pathway mainly regulates anti-inflammatory gene expression and inhibits the progression of inflammation. Therefore, the identification of new Nrf2-dependent anti-inflammatory phytochemicals has become a key point in drug discovery. In this review, we discuss the members of the Keap1/Nrf2/ARE signal pathway and its downstream genes, the effects of this pathway on animal models of inflammatory diseases, and crosstalk with the NF-{$kappa$}B pathway. In addition we also discuss about the regulation of NLRP3 inflammasome by Nrf2. Besides this, we summarize the current scenario of the development of anti-inflammatory phytochemicals and others that mediate the Nrf2/ARE signaling pathway.}
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