BioAcyl Corp
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Wilson, D. F. (2013). Regulation of cellular metabolism: programming and maintaining metabolic homeostasis. J. Appl. Physiol. Added by: Dr. Enrique Feoli (17/02/2021, 23:32) Last edited by: Dr. Enrique Feoli (17/02/2021, 23:33) |
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| Resource type: Journal Article BibTeX citation key: Wilson2013 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Adenylate energy system Creators: Wilson Collection: J. Appl. Physiol. |
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| Abstract |
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Mitochondrial oxidative phosphorylation is programmed to set and maintain metabolic homeostasis. This is accomplished through an intrinsic program that determines the metabolic [ATP]/[ADP]/[Pi], where [Pi] is the concentration of inorganic phosphate (energy state) and maintains it through a bidirectional sensory/signaling control network that reaches every aspect of cellular metabolism. The program sets the energy state with high precision (to better than one part in 109) and can respond to transient changes in energy demand (ATP use) to more than 100 times the resting rate. Epigenetic and environmental factors are able to “fine tune” the programmed set point over a narrow range to meet the special needs associated with cell differentiation and chronic changes in metabolic requirements. The result is robust, across platform control of metabolism, essential to cellular differentiation and the evolution of complex organisms.
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