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Bonaccio, M., Di Castelnuovo, A., Pounis, G., & others. (2016). A score of low-grade inflammation and risk of mortality: prospective findings from the Moli-sani study. Haematologica, 101(11), 1434. Added by: Dr. Enrique Feoli (16/02/2021, 00:31) Last edited by: Dr. Enrique Feoli (16/02/2021, 01:39) |
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| Resource type: Journal Article DOI: 10.3324/haematol.2016.144055 BibTeX citation key: Bonaccio2016 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp Subcategories: Inflammation and mortality, Network Medicine Creators: Bonaccio, Di Castelnuovo, others, Pounis Collection: Haematologica |
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| Abstract |
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Low-grade inflammation is associated with an increased risk of chronic degenerative disease, but its relationship with mortality is less well explored. We aimed at evaluating, at a large epidemiological level, the possible association of low-grade inflammation, as measured by a composite score, with overall mortality risk. We conducted a population-based prospective investigation on 20,337 adult subjects free from major hematological disease and acute inflammatory status, randomly recruited from the general population of the Moli-sani study. A low-grade inflammation score was obtained from the sum of 10-tiles of plasmatic (C-reactive protein) and cellular (leukocyte and platelet counts, granulocyte/lymphocyte ratio) biomarkers of low-grade inflammation; higher levels indicated increased low-grade inflammation. Hazard ratios were calculated using multivariable Cox proportional hazard models with 95% confidence intervals. At the end of follow-up (median 7.6 years), 837 all-cause deaths were recorded. As compared to subjects in the lowest quartile of the low-grade inflammation score, those in the highest category had a significantly increased risk in overall mortality (HR=1.44; 1.17–1.77), independently of possible confounders, including the presence of chronic diseases and a number of health-related behaviors. The magnitude of the association of low-grade inflammation with mortality was relatively higher in type 2 diabetic patients (HR=2.90; 1.74–4.84) and in individuals with a history of cardiovascular disease (HR=2.48; 1.50–4.11) as compared to their counterparts who were free from the disease. In conclusion, an elevated degree of low-grade inflammation, as measured by a composite score of inflammatory biomarkers, is an independent risk factor for total mortality in an apparently healthy adult general population.
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