BioAcyl Corp
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Netea, M. G., Domínguez-Andés, Barreiro, L. B., & others. (2020). Defining trained immunity and its role in health and disease. Nat. Rev. Immunol. 20(6), 375. Added by: Dr. Enrique Feoli (03/02/2021, 02:53) Last edited by: Dr. Enrique Feoli (04/02/2021, 14:43) |
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| Resource type: Journal Article DOI: 10.1038/s41577-020-0285-6 BibTeX citation key: Netea2020 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Trained immunity Creators: Barreiro, Domínguez-Andés, Netea, others Collection: Nat. Rev. Immunol. |
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| Abstract |
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{Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed {`}trained immunity{'}, a de facto ...}Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
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