BioAcyl Corp
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Turner, D. L., Bickham, K. L., Thome, J. J., Kim, C. Y., D'Ovidio, F., & Wherry, E. J., et al. (2014). Lung niches for the generation and maintenance of tissue-resident memory T cells. Mucosal Immunology, 7(3), 501–510. Added by: Dr. Enrique Feoli (31/01/2021, 18:23) Last edited by: Dr. Enrique Feoli (31/01/2021, 18:25) |
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| Resource type: Journal Article DOI: 10.1038/mi.2013.67 ID no. (ISBN etc.): 1935-3456 BibTeX citation key: Turner2014 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp, BioAcyl Corp Subcategories: Inflammatory memory, Microenvironment, Tcell types Cell-mediated effector immunity Creators: Bickham, D'Ovidio, Farber, Kim, Thome, Turner, Wherry Collection: Mucosal Immunology |
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| Abstract |
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{The extent to which tissue-specific viral infections generate memory T cells specifically adapted to and maintained within the target infection site is unknown. Here, we show that respiratory virus-specific memory T cells in mice and humans are generated and maintained in compartmentalized niches in lungs, distinct from populations in lymphoid tissue or circulation. Using a polyclonal mouse model of influenza infection combined with an in vivo antibody labeling approach and confocal imaging, we identify a spatially distinct niche in the lung where influenza-specific T-cell responses are expanded and maintained long term as tissue-resident memory (TRM) CD4 and CD8 T cells. Lung TRM are further distinguished from circulating memory subsets in lung and spleen based on CD69 expression and persistence independent of lymphoid stores. In humans, influenza-specific T cells are enriched within the lung TRM subset, whereas memory CD8 T cells specific for the systemic virus cytomegalovirus are distributed in both lung and spleen, suggesting that the site of infection affects TRM generation. Our findings reveal a precise spatial organization to virus-specific T-cell memory, determined by the site of the initial infection, with important implications for the development of targeted strategies to boost immunity at appropriate tissue sites.}
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