BioAcyl Corp
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Tomofuji, T., Irie, K., Sanbe, T., Azuma, T., Ekuni, D., & Tamaki, N., et al. (2009). Periodontitis and increase in circulating oxidative stress. Japanese Dental Science Review, 45(1), 46–51. Added by: Dr. Enrique Feoli (19/01/2021, 18:42) Last edited by: Dr. Enrique Feoli (19/01/2021, 18:44) |
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| Resource type: Journal Article DOI: 10.1016/j.jdsr.2008.12.002 ID no. (ISBN etc.): 1882-7616 BibTeX citation key: Tomofuji2009 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Perodontitis Creators: Azuma, Ekuni, Irie, Morita, Sanbe, Tamaki, Tomofuji, Yamamoto Collection: Japanese Dental Science Review |
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| Abstract |
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Reactive oxygen species (ROS) are products of normal cellular metabolism. However, excessive production of ROS oxidizes DNA, lipids and proteins, inducing tissue damage. Studies have shown that periodontitis induces excessive ROS production in periodontal tissue. When periodontitis develops, ROS produced in the periodontal lesion diffuse into the blood stream, resulting in the oxidation of blood molecules (circulating oxidative stress). Such oxidation may be detrimental to systemic health. For instance, previous animal studies suggested that experimental periodontitis induces oxidative damage of the liver and descending aorta by increasing circulating oxidative stress. In addition, it has been revealed that clinical parameters in chronic periodontitis patients showed a significant improvement 2 months after periodontal treatment, which was accompanied by a significant reduction of reactive oxygen metabolites in plasma. Improvement of periodontitis by periodontal treatment could reduce the occurrence of circulating oxidative stress. Furthermore, recent studies indicate that the increase in circulating oxidative stress following diabetes mellitus and inappropriate nutrition damages periodontal tissues. In such cases, therapeutic approaches to systemic oxidative stress might be necessary to improve periodontal health.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |