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Misteli, T. (2020). The Self-Organizing Genome: Principles of Genome Architecture and Function. Cell, 183(1), 28–45. Added by: Dr. Enrique Feoli (24/11/2020, 19:11) Last edited by: Dr. Enrique Feoli (24/11/2020, 19:12) |
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| Resource type: Journal Article DOI: 10.1016/j.cell.2020.09.014 ID no. (ISBN etc.): 1097-4172 BibTeX citation key: Misteli2020 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Bioenergetics Creators: Misteli Collection: Cell |
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| Abstract |
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Genomes have complex three-dimensional architectures. The recent convergence of genetic, biochemical, biophysical, and cell biological methods has uncovered several fundamental principles of genome organization. They highlight that genome function is a major driver of genome architecture and that structural features of chromatin act as modulators, rather than binary determinants, of genome activity. The interplay of these principles in the context of self-organization can account for the emergence of structural chromatin features, the diversity and single-cell heterogeneity of nuclear architecture in cell types and tissues, and explains evolutionarily conserved functional features of genomes, including plasticity and robustness.
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