BioAcyl Corp
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Pizzolla, A., Wang, Z., Groom, J. R., Kedzierska, K., Brooks, A. G., & Reading, P. C., et al. (2017). Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells. Proc. Natl. Acad. Sci. U.S.A. 201620194. Added by: Dr. Enrique Feoli (19/10/2020, 17:36) Last edited by: Dr. Enrique Feoli (19/10/2020, 17:37) |
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| Resource type: Journal Article DOI: 10.1073/pnas.1620194114 ID no. (ISBN etc.): 0027-8424 BibTeX citation key: Pizzolla2017 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: COVID-19 Tcell memory Creators: Brooks, Groom, Kedzierska, Pizzolla, Reading, Wakim, Wang Collection: Proc. Natl. Acad. Sci. U.S.A. |
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| Abstract |
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The lymphoid tissue that drains the upper respiratory tract represents an important induction site for cytotoxic T lymphocyte (CTL) immunity to airborne pathogens and intranasal vaccines. Here, we investigated the role of the nasal-associated lymphoid tissues (NALTs), which are mucosal-associated lymphoid organs embedded in the submucosa of the nasal passage, in the initial priming and recall expansion of CD8+ T cells following an upper respiratory tract infection with a pathogenic influenza virus and immunization with a live attenuated influenza virus vaccine. Whereas NALTs served as the induction site for the recall expansion of memory CD8+ T cells following influenza virus infection or vaccination, they failed to support activation of na{ifmmodeddot{imath}else"{i}fi}ve CD8+ T cells. Strikingly, NALTs, unlike other lymphoid tissues, were not routinely surveyed during the steady state by circulating T cells. The selective recruitment of memory T cells into these lymphoid structures occurred in response to infection-induced elevation of the chemokine CXCL10, which attracted CXCR3+ memory CD8+ T cells. These results have significant implications for intranasal vaccines, which deliver antigen to mucosal-associated lymphoid tissue and aim to elicit protective CTL-mediated immunity.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |