BioAcyl Corp
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Merkley, S. D., Chock, C. J., Yang, X. O., Harris, J., & Castillo, E. F. (2018). Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells. Frontiers in immunology, 9. Added by: Dr. Enrique Feoli (10/10/2020, 18:47) Last edited by: Dr. Enrique Feoli (10/10/2020, 18:50) |
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| Resource type: Journal Article DOI: 10.3389/fimmu.2018.02914 ID no. (ISBN etc.): 1664-3224 BibTeX citation key: Merkley2018 View all bibliographic details  |
Categories: BioAcyl Corp, Mendeley Subcategories: Autophagy, mitophagy, Tcell redox activation Creators: Castillo, Chock, Harris, Merkley, Yang Collection: Frontiers in immunology |
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| Abstract |
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Autophagy is a homeostatic and inducible process affecting multiple aspects of the immune system. This intrinsic cellular process is involved in MHC-antigen (Ag) presentation, inflammatory signaling, cytokine regulation and cellular metabolism. In the context of T cell responses, autophagy has an influential hand in dictating responses to self and non-self by controlling extrinsic factors (e.g. MHC-Ag, cytokine production) in antigen-presenting cells (APC) and intrinsic factors (e.g. cell signaling, survival, cytokine production and metabolism) in T cells. These attributes make autophagy an attractive therapeutic target to modulate T cell responses. In this review, we examine the impact autophagy has on T cell responses by modulating multiple aspects of APC function; the importance of autophagy in the activation, differentiation and homeostasis of T cells; and discuss how the modulation of autophagy could influence T cell responses.
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