BioAcyl Corp
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Wilmore, J. R., & Allman, D. (2017). Here, there, and anywhere? Arguments for and against the physical plasma cell survival niche. Journal of immunology (Baltimore, Md. : 1950), 199(3), 839. Added by: Dr. Enrique Feoli (06/10/2020, 20:22) Last edited by: Dr. Enrique Feoli (07/10/2020, 08:28) |
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| Resource type: Journal Article DOI: 10.4049/jimmunol.1700461 BibTeX citation key: Wilmore2017 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp Subcategories: Inmunidad de mucosas, Long lived plasma cells Creators: Allman, Wilmore Collection: Journal of immunology (Baltimore, Md. : 1950) |
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| Abstract |
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{To maintain antibody titers individual plasma cells must survive for extended periods, perhaps even for the life of the host. While it is clear that plasma cell survival requires cell extrinsic signals, the nature and source of these signals remains open for debate. It is commonly postulated that plasma cells only gain access to these signals within specialized regulatory microenvironments, or niches, in the bone marrow or in the gut. Here we discuss current concepts and information surrounding plasma cell survival niches, and consider two opposing models to explain long-term serologic immunity.}
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| Notes |
The physical niche model is characterized by specialized locations within the bone marrow that supply essential survival factors. Stromal cells attract plasma cells by providing CXCL12 and additional survival factors such as IL-6. Plasma cell survival requires a ligand for BCMA, in this case APRIL, which is provided by various cell types including eosinophils, basophils, and megakaryocytes. Mature plasma cells fill the niche requiring immature plasma cells to compete for survival factors leading to a limited number of immature cells continuing their maturation. (B) The free access model states that plasma cells are drawn to any CXCL12 source and are not limited to dedicated niches. Mature and immature plasma cells are attracted equally and are supplied by survival factors that are systemically available such as APRIL, BLyS, and IL-6. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |