Influenza vaccine-induced human bone marrow plasma cells decline within a year after vaccination

Davis, Carl W.; Jackson, Katherine J. L.; McCausland, Megan M.; Darce, Jaime; Chang, Cathy; Linderman, Susanne L.; Chennareddy, Chakravarthy; Gerkin, Rebecca; Brown, Shantoria J.; Wrammert, Jens; Mehta, Aneesh K.; Cheung, Wan Cheung; Boyd, Scott D.; Waller, Edmund K.; Ahmed, Rafi

doi:10.1126/science.aaz8432

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BioAcyl Corp

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Davis, C. W., Jackson, K. J. L., McCausland, M. M., Darce, J., Chang, C., & Linderman, S. L., et al. (2020). Influenza vaccine-induced human bone marrow plasma cells decline within a year after vaccination. Science, eaaz8432.
Added by: Dr. Enrique Feoli (06/10/2020, 18:38) Last edited by: Dr. Enrique Feoli (06/10/2020, 18:42)

Resource type: Journal Article
DOI: 10.1126/science.aaz8432
ID no. (ISBN etc.): 0036-8075
BibTeX citation key: Davis2020
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Categories: BioAcyl Corp
Subcategories: Influenza vaccine
Creators: Ahmed, Boyd, Brown, Chang, Chennareddy, Cheung, Darce, Davis, Gerkin, Jackson, Linderman, McCausland, Mehta, Waller, Wrammert
Collection: Science

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Abstract

A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains, but also long-lasting. Because long-term serum antibody levels are maintained by bone marrow plasma cells (BMPC), we investigated the production and maintenance of these cells after influenza vaccination. We found increased numbers of influenza-specific BMPC four weeks after immunization with the seasonal inactivated influenza vaccine, but numbers returned to near their pre-vaccination levels after one year. This decline was driven by the loss of BMPC induced by the vaccine, while pre-existing BMPC were maintained. Our results suggest that most BMPC generated by influenza vaccination in adults are short-lived. Designing strategies to enhance their persistence will be a key challenge for the next generation of influenza vaccines.