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Iwaszkiewicz, K., Schneider, J., & Hua, S. (2013). Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions. Frontiers in Pharmacology, 4, 132. Added by: Dr. Enrique Feoli (18/08/2020, 12:02) Last edited by: Dr. Enrique Feoli (18/08/2020, 12:04) |
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| Resource type: Journal Article DOI: 10.3389/fphar.2013.00132 ID no. (ISBN etc.): 1663-9812 BibTeX citation key: Iwaszkiewicz2013 View all bibliographic details  |
Categories: Mendeley Subcategories: Analgesia Creators: Hua, Iwaszkiewicz, Schneider Collection: Frontiers in Pharmacology |
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| Abstract |
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Mechanisms of endogenous pain control are significant. Increasing studies have clearly produced evidence for the clinical usefulness of opioids in peripheral analgesia. The immune system uses mechanisms of cell migration not only to fight pathogens but also to control pain and inflammation within injured tissue. It has been demonstrated that peripheral inflammatory pain can be effectively controlled by an interaction of immune cell-derived opioid peptides with opioid receptors on peripheral sensory nerve terminals. Experimental and clinical studies have clearly shown that activation of peripheral opioid receptors with exogenous opioid agonists and endogenous opioid peptides are able to produce significant analgesic and anti-inflammatory effects, without central opioid mediated side effects (e.g., respiratory depression, sedation, tolerance, dependence). This article will focus on the role of opioids in peripheral inflammatory conditions and the clinical implications of targeting peripheral opioid receptors.
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