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Chmilewsky, F., Jeanneau, C., Dejou, J., & About, I. (2014). Sources of Dentin-Pulp Regeneration Signals and Their Modulation by the Local Microenvironment. Journal of Endodontics, 40(4), S19–S25. 
Added by: Dr. Enrique Feoli (23/07/2020, 18:47)   Last edited by: Dr. Enrique Feoli (15/04/2023, 13:33)
Resource type: Journal Article
DOI: 10.1016/j.joen.2014.01.012
ID no. (ISBN etc.): 0099-2399, 1878-3554
BibTeX citation key: Chmilewsky2014
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 Categories: BioAcyl Corp
Subcategories: Dentin-Pulp interface
Creators: About, Chmilewsky, Dejou, Jeanneau
Collection: Journal of Endodontics
Resources citing this (Bibliography: WIKINDX Master Bibliography)		 Views: 2/953
Abstract
Abstract: Many aspects of dentin pulp tissue regeneration have been investigated, and it has been shown that dentin pulp has a high regeneration capacity. This seems to be because of the presence of progenitor cells and inductive regeneration signals from different origins. These signals can be liberated after the acidic dissolution of carious dentin as well as from pulp fibroblasts and endothelial cells in cases of traumatic injury. Thus, both carious lesions and pulp cells provide the required mediators for complete dentin-pulp regeneration including reparative dentin secretion, angiogenesis, and innervation. Additionally, all dentin pulp insults including carious "infection," traumatic injuries, application of restorative materials on the injured dentin pulp, and subsequent apoptosis are known activators of the complement system. This activation leads to the production of several biologically active fragments responsible for the vascular modifications and the attraction of immune cells to the inflammatory/injury site. Among these, C5a is involved in the recruitment of pulp progenitor cells, which express the C5a receptor. Thus, in addition to dentin and pulp cells, plasma should be considered as an additional source of regeneration signals.
  
Notes
Publisher: Elsevier

Esclarece por qué controlando el microambiente de la interfaz pulpa-dentina es posible regenerar caries dentinales.

Complement activation C5a


Added by: Dr. Enrique Feoli  Last edited by: Dr. Enrique Feoli
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