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Luo, Y., & Liu, M. (2016). Adiponectin: A versatile player of innate immunity. Journal of Molecular Cell Biology, 8(2), 120–128. Added by: Dr. Enrique Feoli (06/05/2026, 09:57) Last edited by: Dr. Enrique Feoli (06/05/2026, 10:00) |
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| Resource type: Journal Article DOI: 10.1093/jmcb/mjw012 ID no. (ISBN etc.): 1674-2788 BibTeX citation key: Luo2016 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Adiponectin Creators: Liu, Luo Collection: Journal of Molecular Cell Biology |
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| Abstract |
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Adiponectin acts as a key regulator of the innate immune system and plays a major role in the progression of inflammation and metabolic disorders. Macrophages and monocytes are representative components of the innate immune system, and their proliferation, plasticity, and polarization are a key component of metabolic adaption. Innate-like lymphocytes such as group 2 innate lymphoid cells (ILC2s), natural killer T (NKT) cells, and gamma delta T (γδ T) cells are also members of the innate immune system and play important roles in the development of obesity and its related diseases. Adiponectin senses metabolic stress and modulates metabolic adaption by targeting the innate immune system under physiological and pathological conditions. Defining the mechanisms underlying the role of adiponectin in regulating innate immunity is crucial to adiponectin-based therapeutic intervention.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
| Notes |
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Adiponectin plays a critical role in the regulation of non-macrophage innate immune cells. Accumulating data suggest that adiponectin suppresses the activation of eosinophils, neutrophils, γδ T cells, NK cells, and DCs through common or different intracellular signaling pathways, whereas adiponectin appears to have little effect on recruitment and activation of ILC2 in adipose tissue under chronic cold stress. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
