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Slavik, K. M., & Kranzusch, P. J. (2023). CBASS to cGAS-STING: The Origins and Mechanisms of Nucleotide Second Messenger Immune Signaling. Annual Review of Virology, 10(Volume 10, 2023), 423–453. Added by: Dr. Enrique Feoli (13/04/2026, 11:47) Last edited by: Dr. Enrique Feoli (13/04/2026, 11:51) |
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| Resource type: Journal Article DOI: 10.1146/annurev-virology-111821-115636 ID no. (ISBN etc.): 2327-0578 BibTeX citation key: Slavik2023 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Liquid-liquid phase separations Keywords: Innate immunity Creators: Kranzusch, Slavik Collection: Annual Review of Virology |
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| Abstract |
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Host defense against viral pathogens is an essential function for all living organisms. In cell-intrinsic innate immunity, dedicated sensor proteins recognize molecular signatures of infection and communicate to downstream adaptor or effector proteins to activate immune defense. Remarkably, recent evidence demonstrates that much of the core machinery of innate immunity is shared across eukaryotic and prokaryotic domains of life. Here, we review a pioneering example of evolutionary conservation in innate immunity: the animal cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) signaling pathway and its ancestor in bacteria, CBASS (cyclic nucleotide-based antiphage signaling system) antiphage defense. We discuss the unique mechanism by which animal cGLRs (cGAS-like receptors) and bacterial CD-NTases (cGAS/dinucleotide-cyclase in Vibrio (DncV)-like nucleotidyltransferases) in these pathways link pathogen detection with immune activation using nucleotide second messenger signals. Comparing the biochemical, structural, and mechanistic details of cGAS-STING, cGLR signaling, and CBASS, we highlight emerging questions in the field and examine evolutionary pressures that may have shaped the origins of nucleotide second messenger signaling in antiviral defense.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
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Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
