Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment

Andersen, Anne Poder; Flinck, Mette; Oernbo, Eva Kjer

doi:10.1186/s12943-016-0528-0

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BioAcyl Corp

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Andersen, A. P., Flinck, M., & Oernbo, E. K. (2016). Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment. Molecular Cancer, 15(1), 45.
Added by: Dr. Enrique Feoli (12/09/2025, 22:53) Last edited by: Dr. Enrique Feoli (12/09/2025, 23:00)

Resource type: Journal Article
DOI: 10.1186/s12943-016-0528-0
ID no. (ISBN etc.): 1476-4598
BibTeX citation key: Andersen2016
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Categories: BioAcyl Corp
Subcategories: Perivascular microenvironment
Keywords: Acid–base transport, acidic environment, Interstitial pH Dynamics, MCT1, MCT4, NBCn1, NHE1, Tumor microenvironment
Creators: Andersen, Flinck, Oernbo
Collection: Molecular Cancer

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Abstract

The 3-dimensional (3D) microenvironment of breast carcinomas is characterized by profoundly altered pH homeostasis, reflecting increased metabolic acid production and a confined extracellular space characterized by poor diffusion, yet the relative contributions of specific pH-regulatory transporters to 3D growth are poorly understood. The aim of this work was to determine how 3D spheroid growth of breast cancer cells impacts the expression and spatial organization of major acid extruding proteins, and how these proteins in turn are required for spheroid growth.