BioAcyl Corp
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Pedersen, S. F., & Boedtkjer, E. (2025). Introducing a special issue: Acid–base regulation and sensing in health and disease. Acta Physiologica, 241(4), e70021. Added by: Dr. Enrique Feoli (12/09/2025, 22:30) Last edited by: Dr. Enrique Feoli (12/09/2025, 22:35) |
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| Resource type: Journal Article DOI: 10.1111/apha.70021 BibTeX citation key: Pedersen2025 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Perivascular microenvironment Keywords: Interstitial pH Dynamics Creators: Boedtkjer, Pedersen Collection: Acta Physiologica |
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| Abstract |
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Cell metabolism continuously generates acid, primarily in the form of H+ from fermentation and CO2 from oxidative phosphorylation. However, the normal physiological functions at all levels of biological organization depend on pH being regulated within narrow ranges. The homeostatic regulation of acid–base status is therefore fundamentally important in virtually all aspects of physiology. At the cellular and organellar level, ion transport proteins import and export acids and bases across membranes, and passive H+-buffering systems limit changes in pH upon acid–base challenges and facilitate H+ movement to and from sites of production and transport. Signaling events—initiated, for example, by H+-sensing G-protein coupled receptors, ion channels, and transmembrane or soluble HCO3−-sensing proteins1—control the expression and activity of the pH regulatory systems and produce functional adaptations in response to acid–base disturbances. In vertebrates, acid extruded from cells enters the vasculature and moves via the blood to the lungs and kidneys where it is finally eliminated.
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| Notes |
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e70021 APH-2025-02-0087
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