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Wang, A., Luan, H. H., & Medzhitov, R. (2019). An evolutionary perspective on immunometabolism. Science, 363(6423), eaar3932. Added by: Dr. Enrique Feoli (02/08/2025, 01:54) Last edited by: Dr. Enrique Feoli (02/08/2025, 01:54) |
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| Resource type: Journal Article DOI: 10.1126/science.aar3932 BibTeX citation key: Wang2019 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Peer review Creators: Luan, Medzhitov, Wang Collection: Science |
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| Abstract |
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All living organisms need energy and metabolic building blocks to sustain biological processes. Wang et al. review immunometabolism, applying the principles of life history theory. They highlight recent advances showing the reciprocal interactions between systemic metabolism and immunity, as well as how inflammation can alter the functional state of metabolic organs and their central control by the hypothalamus. Such coordinated cross-talk between whole-body and immune cell metabolism is involved in a variety of health and disease states. Science, this issue p. eaar3932 Metabolism is at the core of all biological functions. Anabolic metabolism uses building blocks that are either derived from nutrients or synthesized de novo to produce the biological infrastructure, whereas catabolic metabolism generates energy to fuel all biological processes. Distinct metabolic programs are required to support different biological functions. Thus, recent studies have revealed how signals regulating cell quiescence, proliferation, and differentiation also induce the appropriate metabolic programs. In particular, a wealth of new studies in the field of immunometabolism has unveiled many examples of the connection among metabolism, cell fate decisions, and organismal physiology. We discuss these findings under a unifying framework derived from the evolutionary and ecological principles of life history theory.
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