BioAcyl Corp
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Baglioni, E. A., Perego, F., & Paolin, E. (2024). Efficacy of autologous micrografts technology: A promising approach for chronic wound healing and tissue regeneration—a pilot study. Frontiers in Medicine, Volume 11 - 2024. Added by: Dr. Enrique Feoli (20/07/2025, 23:53) Last edited by: Dr. Enrique Feoli (20/07/2025, 23:54) |
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| Resource type: Journal Article DOI: 10.3389/fmed.2024.1417920 ID no. (ISBN etc.): 2296-858X BibTeX citation key: Baglioni2024 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Aurologous micrografts Creators: Baglioni, Paolin, Perego Collection: Frontiers in Medicine |
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| Abstract |
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This study explores the efficacy of Autologous Micrografts Technology (AMG) in treating chronic wounds refractory to traditional therapies. AMGs, derived from adipose tissue or dermis using a mechanical fragmentation process, were applied to patients with post-surgical dehiscence. A comprehensive evaluation of wound healing outcomes, including surface area reduction and complete healing, was conducted over a 90-day follow-up period. Additionally, the study investigated the cellular antioxidant activity of AMG solutions and characterized the exosomes obtained through mechanical disaggregation. Results indicate significant improvements (p{<}0,05) in wound healing, with 91.66\% of patients showing at least a 50\% reduction in lesion size and 75\% achieving complete healing by day 90. Notably, AMG technology demonstrated immediate efficacy with fat-only application, while combined dermis and fat micrografts showed longer-term benefits, particularly in chronic wounds. The study also elucidated the mechanism of action of AMGs, highlighting their role in enhancing cellular antioxidant activity and exosome-mediated tissue regeneration. Overall, these findings underscore the promising potential of AMG technology as a versatile and effective treatment option for chronic wounds, warranting further investigation into its mechanisms and clinical applications.
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