BioAcyl Corp
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Ly, H. C., Lynch, G. S., & Ryall, J. G. (2020). A Metabolic Roadmap for Somatic Stem Cell Fate. Cell Metabolism, 31(5), 1052–1067. Added by: Dr. Enrique Feoli (12/07/2025, 22:31) Last edited by: Dr. Enrique Feoli (12/07/2025, 22:37) |
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| Resource type: Journal Article ID no. (ISBN etc.): 1550-4131 BibTeX citation key: Ly2020 View all bibliographic details  |
Categories: BioAcyl Corp Keywords: carbohydrates, Epigenetics, glycolysis, Metabolism, Reprogramming Creators: Ly, Lynch, Ryall Publisher: Cell Press Collection: Cell Metabolism |
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| Abstract |
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While metabolism was initially thought to play a passive role in cell biology by generating ATP to meet bioenergetic demands, recent studies have identified critical roles for metabolism in the generation of new biomass and provision of obligate substrates for the epigenetic modification of histones and DNA. This review details how metabolites generated through glycolysis and the tricarboxylic acid cycle are utilized by somatic stem cells to support cell proliferation and lineage commitment. Importantly, we also discuss the evolving hypothesis that histones can act as an energy reservoir during times of energy stress. Finally, we discuss how cells integrate both extrinsic metabolic cues and intrinsic metabolic machinery to regulate cell fate.
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| Notes |
The pentose phosphate pathway (PPP) and serine synthesis pathway (SSP) branch from glycolysis and are responsible for the generation of a number of important macromolecules essential in proliferating cells. The SSP also feeds the one-carbon cycle, which gives rise to S-adenosylmethionine (SAM), which can be utilized to methylate both histones and DNA by the actions of DNA methyltransferase (DNMT) while the removal of the methyl group is facilitated by the ten-eleven translocase (TET) family of DNA demethylases and requires α-ketoglutarate (αKG) as an obligate cofactor. Acetyl-CoA generated from the decarboxylation of pyruvate can be transported to the nucleus, where it serves as the acetyl donor for histone acetylation. In this manner, metabolism is interlinked with both the proliferation and epigenetic regulation of cells Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |