BioAcyl Corp
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Wang, L., & Zhou, W. (2024). Phase separation as a new form of regulation in innate immunity. Molecular cell, 64(13). Added by: Dr. Enrique Feoli (07/05/2025, 00:03) Last edited by: Dr. Enrique Feoli (12/06/2025, 20:14) |
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| Resource type: Journal Article Peer reviewed DOI: 10.1016/j.molcel.2024.06.004 BibTeX citation key: Wang2024 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp Subcategories: Constitutive innate immunity, Liquid-liquid phase separations Keywords: cGAS-STING signaling, DNA sensing, evolution, Innate immunity, LLPS, phase separation, RNA sensing Creators: Wang, Zhou Publisher: Cell Press Collection: Molecular cell |
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| Abstract |
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Innate immunity is essential for the host against pathogens, cancer, and autoimmunity. The innate immune system encodes many sensor, adaptor, and effector proteins and relies on the assembly of higher-order signaling complexes to activate immune defense. Recent evidence demonstrates that many of the core complexes involved in innate immunity are organized as liquid-like condensates through a mechanism known as phase separation. Here, we discuss phase-separated condensates and their diverse functions. We compare the biochemical, structural, and mechanistic details of solid and liquid-like assemblies to explore the role of phase separation in innate immunity. We summarize the emerging evidence for the hypothesis that phase separation is a conserved mechanism that controls immune responses across the tree of life. The discovery of phase separation in innate immunity provides a new foundation to explain the rules that govern immune system activation and will enable the development of therapeutics to treat immune-related diseases properly.
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