BioAcyl Corp
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Costa-Mattioli, M., & Walter, P. (2020). The integrated stress response: From mechanism to disease. Science (New York, N.Y.), 368(6489), eaat5314. Added by: Dr. Enrique Feoli (18/04/2025, 01:53) Last edited by: Dr. Enrique Feoli (27/02/2026, 19:10) |
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| Resource type: Journal Article DOI: 10.1126/science.aat5314 ID no. (ISBN etc.): 0036-8075 BibTeX citation key: CostaMattioli2020 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Stress response, Tissue specific response Creators: Costa-Mattioli, Walter Collection: Science (New York, N.Y.) |
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| Abstract |
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, The regulatory network of the ISR. Diverse deviations from homeostasis activate the ISR. The resulting dysregulation of translation contributes to numerous diseases., Protein quality control is essential for the proper function of cells and the organisms that they make up. The resulting loss of proteostasis, the processes by which the health of the cell’s proteins is monitored and maintained at homeostasis, is associated with a wide range of age-related human diseases. Here, we highlight how the integrated stress response (ISR), a central signaling network that responds to proteostasis defects by tuning protein synthesis rates, impedes the formation of long-term memory. In addition, we address how dysregulated ISR signaling contributes to the pathogenesis of complex diseases, including cognitive disorders, neurodegeneration, cancer, diabetes, and metabolic disorders. The development of tools through which the ISR can be modulated promises to uncover new avenues to diminish pathologies resulting from it for clinical benefit.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
| Notes |
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Several lines of evidence indicate that the ISR is intimately embedded in the cell’s innate immune response (198, 199). All four ISR kinases play parts in immunity and inflammation. ISR activation leads to secretion of inflammatory cytokines, such as interleukin 1β (IL-1β) and IL6. In this way, ISR signaling does not remain cell autonomous and promotes communication between neighboring cells in a state of local inflammation. Pharmacologic ISR inhibition may therefore have broadly beneficial anti-inflammatory consequences.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |