Gut integrity in intensive care: alterations in host permeability and the microbiome as potential therapeutic targets

Oami, Takehiko; Shimazui, Takashi; Yumoto, Tetsuya

doi:10.1186/s40560-025-00786-y

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BioAcyl Corp

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Oami, T., Shimazui, T., & Yumoto, T. (2025). Gut integrity in intensive care: Alterations in host permeability and the microbiome as potential therapeutic targets. Journal of Intensive Care, 13(1), 16.
Added by: Dr. Enrique Feoli (05/04/2025, 19:37) Last edited by: Dr. Enrique Feoli (05/04/2025, 19:39)

Resource type: Journal Article
DOI: 10.1186/s40560-025-00786-y
ID no. (ISBN etc.): 2052-0492
BibTeX citation key: Oami2025
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Categories: BioAcyl Corp
Subcategories: Gut-origin Sepsis
Keywords: , , , , , , , , ,
Creators: Oami, Shimazui, Yumoto
Collection: Journal of Intensive Care

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Abstract

The gut has long been hypothesized to be the “motor” of critical illness, propagating inflammation and playing a key role in multiple organ dysfunction. However, the exact mechanisms through which impaired gut integrity potentially contribute to worsened clinical outcome remain to be elucidated. Critical elements of gut dysregulation including intestinal hyperpermeability and a perturbed microbiome are now recognized as potential therapeutic targets in critical care.