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Nimmerjahn, F., Milosevic, S., & Behrends, U. (2003). Major histocompatibility complex class ii-restricted presentation of a cytosolic antigen by autophagy. European Journal of Immunology, 33(5), 1250–1259. Added by: Dr. Enrique Feoli (02/05/2024, 11:13) Last edited by: Dr. Enrique Feoli (02/05/2024, 11:16) |
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| Resource type: Journal Article BibTeX citation key: Nimmerjahn2003 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Autophagy and mitophagy Keywords: , , , Creators: Behrends, Milosevic, Nimmerjahn Collection: European Journal of Immunology |
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| Abstract |
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Abstract Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from the cytosolic protein neomycin phosphotransferase II (NeoR) on MHC classII is mediated by autophagy. This presentation pathway involves the sequestration of NeoR into autophagosomes, and subsequent delivery into the lytic compartment. These results identify endosomes/lysosomes as the processing compartment for cytosolic antigens and furthermore link endogenous antigen presentation on MHC class II with the process of cellular protein turnover by autophagy.
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