Autophagy Defends Cells Against Invading Group A <em>Streptococcus</em>

Nakagawa, Ichiro; Amano, Atsuo; Mizushima, Noboru

doi:10.1126/science.1103966

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BioAcyl Corp

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Nakagawa, I., Amano, A., & Mizushima, N. (2004). Autophagy defends cells against invading group a streptococcus. Science, 306(5698), 1037–1040.
Added by: Dr. Enrique Feoli (02/05/2024, 09:50) Last edited by: Dr. Enrique Feoli (02/05/2024, 09:54)

Resource type: Journal Article
DOI: 10.1126/science.1103966
BibTeX citation key: Nakagawa2004
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Categories: BioAcyl Corp
Subcategories: Autophagy and mitophagy
Creators: Amano, Mizushima, Nakagawa
Collection: Science

Views: 3/138

Abstract

We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5–/– cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.