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Scharschmidt, T. C., Vasquez, K. S., & Truong, H.-A. (2015). A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity, 43(5), 1011–1021. Added by: Dr. Enrique Feoli (07/11/2023, 15:54) Last edited by: Dr. Enrique Feoli (07/11/2023, 15:55) |
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| Resource type: Journal Article DOI: https://doi.org/10.1016/j.immuni.2015.10.016 ID no. (ISBN etc.): 1074-7613 BibTeX citation key: Scharschmidt2015 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Microbiota on immunity Creators: Scharschmidt, Truong, Vasquez Collection: Immunity |
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| Abstract |
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Summary The skin is a site of constant dialog between the immune system and commensal bacteria. However, the molecular mechanisms that allow us to tolerate the presence of skin commensals without eliciting destructive inflammation are unknown. Using a model system to study the antigen-specific response to S. epidermidis, we demonstrated that skin colonization during a defined period of neonatal life was required for establishing immune tolerance to commensal microbes. This crucial window was characterized by an abrupt influx of highly activated regulatory T (Treg) cells into neonatal skin. Selective inhibition of this Treg cell wave completely abrogated tolerance. Thus, the host-commensal relationship in the skin relied on a unique Treg cell population that mediated tolerance to bacterial antigens during a defined developmental window. This suggests that the cutaneous microbiome composition in neonatal life is crucial in shaping adaptive immune responses to commensals, and disrupting these interactions might have enduring health implications.
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