BioAcyl Corp
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Nosbaum, A., Prevel, N., & Truong, H.-A. (2016). Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing. The Journal of Immunology, 196(5), 2010–2014. Added by: Dr. Enrique Feoli (06/11/2023, 18:59) Last edited by: Dr. Enrique Feoli (06/11/2023, 19:01) |
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| Resource type: Journal Article DOI: 10.4049/jimmunol.1502139 ID no. (ISBN etc.): 0022-1767 BibTeX citation key: Nosbaum2016 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Wound Healing Creators: Nosbaum, Prevel, Truong Collection: The Journal of Immunology |
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| Abstract |
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Foxp3-expressing regulatory T cells (Tregs) reside in tissues where they control inflammation and mediate tissue-specific functions. The skin of mice and humans contain a large number of Tregs; however, the mechanisms of how these cells function in skin remain largely unknown. In this article, we show that Tregs facilitate cutaneous wound healing. Highly activated Tregs accumulated in skin early after wounding, and specific ablation of these cells resulted in delayed wound re-epithelialization and kinetics of wound closure. Tregs in wounded skin attenuated IFN-γ production and proinflammatory macrophage accumulation. Upon wounding, Tregs induce expression of the epidermal growth factor receptor (EGFR). Lineage-specific deletion of EGFR in Tregs resulted in reduced Treg accumulation and activation in wounded skin, delayed wound closure, and increased proinflammatory macrophage accumulation. Taken together, our results reveal a novel role for Tregs in facilitating skin wound repair and suggest that they use the EGFR pathway to mediate these effects.
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