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Sallusto, F., Lenig, D., & Förster, R. (1999). Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature, 401(6754), 708–712. Added by: Dr. Enrique Feoli (15/10/2023, 18:29) Last edited by: Dr. Enrique Feoli (15/10/2023, 18:30) |
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| Resource type: Journal Article DOI: 10.1038/44385 ID no. (ISBN etc.): 1476-4687 BibTeX citation key: Sallusto1999 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Tcell types Cell-mediated effector immunity Creators: Förster, Lenig, Sallusto Collection: Nature |
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| Abstract |
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Naive T lymphocytes travel to T-cell areas of secondary lymphoid organs in search of antigen presented by dendritic cells1,2. Once activated, they proliferate vigorously, generating effector cells that can migrate to B-cell areas or to inflamed tissues3,4,5,6. A fraction of primed T lymphocytes persists as circulating memory cells that can confer protection and give, upon secondary challenge, a qualitatively different and quantitatively enhanced response7,8,9. The nature of the cells that mediate the different facets of immunological memory remains unresolved. Here we show that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets. CCR7- memory cells express receptors for migration to inflamed tissues and display immediate effector function. In contrast, CCR7+ memory cells express lymph-node homing receptors and lack immediate effector function, but efficiently stimulate dendritic cells and differentiate into CCR7- effector cells upon secondary stimulation. The CCR7+ and CCR7- T cells, which we have named central memory (TCM) and effector memory (TEM), differentiate in a step-wise fashion from naive T cells, persist for years after immunization and allow a division of labour in the memory response.
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| Notes |
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Number: 6754 Publisher: Nature Publishing Group
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