Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

Moore, Kevin W.; Vieira, Paulo; Fiorentino, David F.

doi:10.1126/science.2161559

Javascript is disabled or not supported in your browser. JavaScript must be enabled in order for you to use WIKINDX fully. Enable JavaScript through your browser options then try again, otherwise, try using a different browser.

BioAcyl Corp

WIKINDX Resources

Moore, K. W., Vieira, P., & Fiorentino, D. F. (1990). Homology of cytokine synthesis inhibitory factor (il-10) to the epstein-barr virus gene bcrfi. Science, 248(4960), 1230–1234.
Added by: Dr. Enrique Feoli (15/10/2023, 15:58) Last edited by: Dr. Enrique Feoli (15/10/2023, 16:00)

Resource type: Journal Article
DOI: 10.1126/science.2161559
BibTeX citation key: Moore1990
View all bibliographic details

Categories: BioAcyl Corp
Subcategories: Microenvironment
Creators: Fiorentino, Moore, Vieira
Collection: Science

Views: 2/65

Abstract

Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.