Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

Moore, Kevin W.; Vieira, Paulo; Fiorentino, David F.

doi:10.1126/science.2161559

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Moore, K. W., Vieira, P., & Fiorentino, D. F. (1990). Homology of cytokine synthesis inhibitory factor (il-10) to the epstein-barr virus gene bcrfi. Science, 248(4960), 1230–1234.
Added by: Dr. Enrique Feoli (15/10/2023, 15:58) Last edited by: Dr. Enrique Feoli (15/10/2023, 16:00)

Resource type: Journal Article
DOI: 10.1126/science.2161559
BibTeX citation key: Moore1990
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Categories: BioAcyl Corp
Subcategories: Microenvironment
Creators: Fiorentino, Moore, Vieira
Collection: Science

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Abstract

Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.