BioAcyl Corp
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MacLeod, M. K. L., & David, A. (2011). Memory CD4 T Cells That Express CXCR5 Provide Accelerated Help to B Cells. The Journal of Immunology, 186(5), 2889–2896. Added by: Dr. Enrique Feoli (02/07/2023, 19:42) Last edited by: Dr. Enrique Feoli (02/07/2023, 19:43) |
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| Resource type: Journal Article DOI: 10.4049/jimmunol.1002955 ID no. (ISBN etc.): 0022-1767 BibTeX citation key: MacLeod2011 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Innate Immunity Creators: David, MacLeod Collection: The Journal of Immunology |
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| Abstract |
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CD4 T cell help for B cells is critical for effective Ab responses. Although many of the molecules involved in helper functions of naive CD4 T cells have been characterized, much less is known about the helper capabilities of memory CD4 T cells, an important consideration for the design of vaccines that aim to prime protective memory CD4 T cells. In this study, we demonstrate that memory CD4 T cells enable B cells to expand more rapidly and class switch earlier than do primary responding CD4 T cells. This accelerated response does not require large numbers of memory cells, and similar numbers of primary responding cells provide less effective help than do memory cells. However, only memory CD4 T cells that express the B cell follicle homing molecule, CXCR5, are able to accelerate the response, suggesting that the rapidity of the Ab response depends on the ability of CD4 memory T cells to migrate quickly toward B cells.
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