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Fu, B., Tian, Z., & Wei, H. (2014). Subsets of human natural killer cells and their regulatory effects. Immunology, 141(4), 483–489. Added by: Dr. Enrique Feoli (26/06/2023, 18:48) Last edited by: Dr. Enrique Feoli (26/06/2023, 18:58) |
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| Resource type: Journal Article DOI: https://doi.org/10.1111/imm.12224 BibTeX citation key: Fu2014 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Blastocyst implantation Creators: Fu, Tian, Wei Collection: Immunology |
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| Abstract |
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Summary Human natural killer (NK) cells have distinct functions as NKtolerant, NKcytotoxic and NKregulatory cells and can be divided into different subsets based on the relative expression of the surface markers CD27 and CD11b. CD27+ NK cells, which are abundant cytokine producers, are numerically in the minority in human peripheral blood but constitute the large population of NK cells in cord blood, spleen, tonsil and decidua tissues. Recent data suggest that these NK cells may have immunoregulatory properties under certain conditions. In this review, we will focus on these new NK cell subsets and discuss how regulatory NK cells may serve as rheostats or sentinels in controlling inflammation and maintaining immune homeostasis in various organs.
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| Notes |
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Key pathways of the regulatory decidual natural killer (dNK) cells involved in immune tolerance during the first trimester of human pregnancy. Decidual NK cells with a CD56bright CD16− phenotype can control trophoblast invasion and vascular remodelling, inhibit inflammatory T helper type 17 cells, promote the generation of indoleamine 2,3-dioxygenase (IDO) -producing monocytes and regulatory T cells and induce the apoptosis of effector T cells. Meanwhile, dNK cells are maintained and educated by the decidual microenvironment including stromal cells, trophoblast cells and hormones such as progesterone. IFN-γ, interferon-γ; IL, interleukin; MIC-1, macrophage inhibitory cytokine-1; MIP-1α, macrophage inflammatory protein-1α; PlGF, placental growth factor; SCDF-1, stromal cell-derived factor-1; SCF, stem cell factor; TGF-β, transforming growth factor-β; VEGF, vascular endothelial growth factor.
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