Paligenosis: prepare to regenerate!

Messal, Hendrik A; Cremona, Catherine A; Lan, Linxiang

doi:https://doi.org/10.15252/embj.201899206

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BioAcyl Corp

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Messal, H. A., Cremona, C. A., & Lan, L. (2018). Paligenosis: Prepare to regenerate! The EMBO Journal, 37(7), e99206.
Added by: Dr. Enrique Feoli (24/05/2023, 17:40) Last edited by: Dr. Enrique Feoli (24/05/2023, 17:40)

Resource type: Journal Article
DOI: https://doi.org/10.15252/embj.201899206
BibTeX citation key: Messal2018
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Categories: BioAcyl Corp
Subcategories: Cell plasticity
Creators: Cremona, Lan, Messal
Collection: The EMBO Journal

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Abstract

Tissue injury can stimulate quiescent cells to proliferate, resulting in metaplasia, to rapidly replace damaged cells and enable regeneration. A new study describes how fully differentiated cells return to proliferation in an autophagy- and mTORC1-dependent manner. Given the striking parallels between this process in mammalian stomach and pancreas, a new term, paligenosis, is proposed for this conserved program.