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Zhu, X., Chen, Z., & Shen, W. (2021). Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: The regulation and intervention. Signal Transduction and Targeted Therapy, 6(1), 1–29. 
Added by: Dr. Enrique Feoli (24/05/2023, 15:11)   Last edited by: Dr. Enrique Feoli (24/05/2023, 15:17)
Resource type: Journal Article
DOI: 10.1038/s41392-021-00646-9
ID no. (ISBN etc.): 2059-3635
BibTeX citation key: Zhu2021
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 Categories: BioAcyl Corp
Subcategories: Ageing
Creators: Chen, Shen, Zhu
Collection: Signal Transduction and Targeted Therapy		 Views: 4/164
Abstract
Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing. Epigenetic dynamics and immunometabolic reprogramming link to the alterations of cellular response to intrinsic and extrinsic stimuli, representing current hotspots as they not only (re-)shape the individual cell identity, but also involve in cell fate decision. This review focuses on the present findings and emerging concepts in epigenetic, inflammatory, and metabolic regulations and the consequences of the ageing process. Potential therapeutic interventions targeting cell senescence and regulatory mechanisms, using state-of-the-art techniques are also discussed.
  
Notes

figure 6

Intrinsic cues to metabolic reprogramming during ageing. Six aspects, namely protein homeostasis, genetic and epigenetic instability, organelle dysfunction, redox imbalance, immune response, and altered signaling pathways, lead to the metabolic regulation of ageing


Added by: Dr. Enrique Feoli  Last edited by: Dr. Enrique Feoli
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