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Blanpain, C., & Fuchs, E. (2014). Plasticity of epithelial stem cells in tissue regeneration. Science, 344(6189), 1242281. Added by: Dr. Enrique Feoli (18/05/2023, 17:40) Last edited by: Dr. Enrique Feoli (18/05/2023, 17:41) |
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| Resource type: Journal Article DOI: 10.1126/science.1242281 BibTeX citation key: Blanpain2014 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Stemness Creators: Blanpain, Fuchs Collection: Science |
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| Abstract |
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Stem cells are very important in the maintenance of our bodies' tissues and organs. Blanpain and Fuchs review how different populations of naturally lineage-restricted epithelial stem cells and committed progenitors can also display remarkable plasticity. These cells can reacquire long-term self-renewing capacities and multilineage differentiation potential during physiological and regenerative conditions. These abilities depend on whether the stem cell remains within its resident niche or has been mobilized to repair a wound. Such cellular plasticity has implications for regenerative medicine and for cancer. Science, this issue p. 10.1126/science.1242281 Tissues rely upon stem cells for homeostasis and repair. Recent studies show that the fate and multilineage potential of epithelial stem cells can change depending on whether a stem cell exists within its resident niche and responds to normal tissue homeostasis, whether it is mobilized to repair a wound, or whether it is taken from its niche and challenged to de novo tissue morphogenesis after transplantation. In this Review, we discuss how different populations of naturally lineage-restricted stem cells and committed progenitors can display remarkable plasticity and reversibility and reacquire long-term self-renewing capacities and multilineage differentiation potential during physiological and regenerative conditions. We also discuss the implications of cellular plasticity for regenerative medicine and for cancer.
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