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Jopling, C., Boue, S., & Belmonte, J. C. I. (2011). Dedifferentiation, transdifferentiation and reprogramming: Three routes to regeneration. Nature Reviews Molecular Cell Biology, 12(2), 79–89. Added by: Dr. Enrique Feoli (18/05/2023, 17:08) Last edited by: Dr. Enrique Feoli (18/05/2023, 17:09) |
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| Resource type: Journal Article Published DOI: 10.1038/nrm3043 ID no. (ISBN etc.): 1471-0080 BibTeX citation key: Jopling2011 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Stemness Creators: Belmonte, Boue, Jopling Collection: Nature Reviews Molecular Cell Biology |
Views: 1/153
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| Abstract |
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The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming.During dedifferentiation, a terminally differentiated cell reverts back to a less-differentiated stage from within its own lineage, which allows it to proliferate. Many regenerative processes have been associated with dedifferentiation.Transdifferentiation sees cells regress to a point when they can switch lineages or can also occur directly between two different cell types.Reprogramming aims to induce differentiated cells into reverting to pluripotency. From here, they can differentiate into almost any cell type.During dedifferentiation and transdifferentiation, well-defined intermediate cell types have been identified. The process of reprogramming seems to be largely stochastic.Dedifferentiation and transdifferentiation can be successfully achieved in vivo, and reprogramming facilitates genetic manipulation such as correcting disease-inducing mutations.
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| Notes |
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Number: 2 Publisher: Nature Publishing Group
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