Understanding the Odd Science of Aging

Kirkwood, Thomas B. L.

doi:10.1016/j.cell.2005.01.027

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BioAcyl Corp

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Kirkwood, T. B. L. (2005). Understanding the Odd Science of Aging. Cell, 120(4), 437–447.
Added by: Dr. Enrique Feoli (23/04/2023, 17:11) Last edited by: Dr. Enrique Feoli (25/04/2023, 12:43)

Resource type: Journal Article
DOI: 10.1016/j.cell.2005.01.027
ID no. (ISBN etc.): 0092-8674, 1097-4172
BibTeX citation key: Kirkwood2005
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Categories: BioAcyl Corp
Subcategories: Ageing
Creators: Kirkwood
Collection: Cell

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Abstract

Evolutionary considerations suggest aging is caused not by active gene programming but by evolved limitations in somatic maintenance, resulting in a build-up of damage. Ecological factors such as hazard rates and food availability influence the trade-offs between investing in growth, reproduction, and somatic survival, explaining why species evolved different life spans and why aging rate can sometimes be altered, for example, by dietary restriction. To understand the cell and molecular basis of aging is to unravel the multiplicity of mechanisms causing damage to accumulate and the complex array of systems working to keep damage at bay.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli

Notes

Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli