Major surgery leads to a proinflammatory phenotype: Differential gene expression following a laparotomy

Dobson, Geoffrey P.; Morris, Jodie L.; Biros, Erik; Davenport, Lisa M.; Letson, Hayley L.

doi:10.1016/j.amsu.2021.102970

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Dobson, G. P., Morris, J. L., Biros, E., Davenport, L. M., & Letson, H. L. (2021). Major surgery leads to a proinflammatory phenotype: Differential gene expression following a laparotomy. Annals of Medicine and Surgery, 71, 102970.
Added by: Dr. Enrique Feoli (02/08/2022, 12:34) Last edited by: Dr. Enrique Feoli (02/08/2022, 15:11)

Resource type: Journal Article
DOI: 10.1016/j.amsu.2021.102970
ID no. (ISBN etc.): 2049-0801
BibTeX citation key: Dobson2021
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Categories: BioAcyl Corp, BioAcyl Corp
Subcategories: Heridas quirúrgicas, Stress response
Creators: Biros, Davenport, Dobson, Letson, Morris
Collection: Annals of Medicine and Surgery

Views: 1/259

Abstract

Image 1 , • A single laparotomy activated a surgical-induced stress response. • This was accompanied by inflammation, immune activation, hypermetabolism and coagulopathy. • A standout result was the pervasive nature of systemic and tissue inflammation. • Our study highlights the dynamic nature of genetic changes underpinning the body's early response to major surgery. • There is an urgent need for new therapies to prevent surgical stress and secondary injury and restore homeostatic balance.