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Chovatiya, R., & Medzhitov, R. (2014). Stress, Inflammation, and Defense of Homeostasis. Molecular cell, 54(2), 281–288. Added by: Dr. Enrique Feoli (10/05/2022, 12:52) Last edited by: Dr. Enrique Feoli (10/05/2022, 12:53) |
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| Resource type: Journal Article DOI: 10.1016/j.molcel.2014.03.030 ID no. (ISBN etc.): 1097-2765 BibTeX citation key: Chovatiya2014a View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Stress response Creators: Chovatiya, Medzhitov Collection: Molecular cell |
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| Abstract |
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Inflammation is traditionally considered a defense response induced by infection or injury. However, inflammation can also be induced by tissue stress and malfunction in the absence of infection or overt tissue damage. Here we discuss the relationship between homeostasis, stress responses and inflammation. Stress responses have cell autonomous and cell extrinsic components, the latter contributing to tissue level adaptation to stress conditions. Inflammation can be thought of as the extreme end of a spectrum that ranges from homeostasis to stress response to bona fide inflammatory response. Inflammation can be triggered by two types of stimuli: extreme deviations of homeostasis or challenges that cause a disruption of homeostasis. This perspective may help to explain qualitative differences and functional outcomes of diverse inflammatory responses.
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