Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism

Campbell, Clarissa; Rudensky, Alexander

doi:10.1016/j.cmet.2019.09.010

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Campbell, C., & Rudensky, A. (2020). Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism. Cell Metabolism, 31(1), 18–25.
Added by: Dr. Enrique Feoli (17/04/2022, 11:53) Last edited by: Dr. Enrique Feoli (17/04/2022, 12:10)

Resource type: Journal Article
DOI: 10.1016/j.cmet.2019.09.010
ID no. (ISBN etc.): 1550-4131
BibTeX citation key: Campbell2020
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Categories: BioAcyl Corp
Subcategories: Tregs
Creators: Campbell, Rudensky
Collection: Cell Metabolism

Views: 4/271

Abstract

Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3 represent a specialized immunosuppressive lineage with a well-recognized, essential function in preventing fatal autoimmunity and inflammation. Recent studies revealed that Treg cells can also exert systemic effects on metabolism and partake in tissue repair, suggesting a dual role for these cells in serving and protecting tissues. Here, we review multiple means by which Treg cells support tissue function and organismal homeostasis.