Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages

Bohnacker, Sina; Hartung, Franziska; Henkel, Fiona; Quaranta, Alessandro; Kolmert, Johan; Priller, Alina; Ud-Dean, Minhaz; Giglberger, Johanna; Kugler, Luisa M.; Pechtold, Lisa; Yazici, Sarah; Lechner, Antonie; Erber, Johanna; Protzer, Ulrike; Lingor, Paul; Knolle, Percy; Chaker, Adam M.; Schmidt-Weber, Carsten B.; Wheelock, Craig E.; Esser-von Bieren, Julia

doi:10.1038/s41385-021-00482-8

Javascript is disabled or not supported in your browser. JavaScript must be enabled in order for you to use WIKINDX fully. Enable JavaScript through your browser options then try again, otherwise, try using a different browser.

BioAcyl Corp

WIKINDX Resources

Bohnacker, S., Hartung, F., Henkel, F., Quaranta, A., Kolmert, J., & Priller, A., et al. (2022). Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages. Mucosal Immunology, 1–10.
Added by: Dr. Enrique Feoli (15/03/2022, 18:27) Last edited by: Dr. Enrique Feoli (15/03/2022, 18:32)

Resource type: Journal Article
DOI: 10.1038/s41385-021-00482-8
ID no. (ISBN etc.): 1935-3456
BibTeX citation key: Bohnacker2022
View all bibliographic details

Categories: BioAcyl Corp, BioAcyl Corp
Subcategories: COVID-19, Inflammation resolution
Creators: Bohnacker, Chaker, Erber, Esser-von Bieren, Giglberger, Hartung, Henkel, Knolle, Kolmert, Kugler, Lechner, Lingor, Pechtold, Priller, Protzer, Quaranta, Schmidt-Weber, Ud-Dean, Wheelock, Yazici
Collection: Mucosal Immunology

Views: 2/294

Abstract

Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of eicosanoids in airway inflammation. Here we report that MDM from SARS-CoV-2-infected individuals with mild disease show an inflammatory transcriptional and metabolic imprint that lasts for at least 5 months after SARS-CoV-2 infection. MDM from convalescent SARS-CoV-2-infected individuals showed a downregulation of pro-resolving factors and an increased production of pro-inflammatory eicosanoids, particularly 5-lipoxygenase-derived leukotrienes. Leukotriene synthesis was further enhanced by glucocorticoids and remained elevated at 3–5 months, but had returned to baseline at 12 months post SARS-CoV-2 infection. Stimulation with SARS-CoV-2 spike protein or LPS triggered exaggerated prostanoid-, type I IFN-, and chemokine responses in post COVID-19 MDM. Thus, SARS-CoV-2 infection leaves an inflammatory imprint in the monocyte/ macrophage compartment that drives aberrant macrophage effector functions and eicosanoid metabolism, resulting in long-term immune aberrations in patients recovering from mild COVID-19.

Notes

Publisher: Nature Publishing Group

Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli